Analysis

Abstract
The purpose of this study was to develop a suitable dissolution test for feverfew products and to investigate the
parthenolide content, disintegration, and dissolution performance of several marketed feverfew products. Parthenolide
content was determined by a validated HPLC method. Disintegration was tested according to the USP requirements for

Abstract
USP Dissolution <711> specifies performance verification testing (PVT) of dissolution Apparatus 1 and 2. Acceptance
criteria are determined from a collaborative study and apply per tablet; i.e., each of the six tablets tested must fall within
the specified acceptance criteria in order to pass. In this Stimuli article, USP proposes changing the form of the acceptance

Abstract
An increasing number of routine laboratory analyses and procedures require the use of gas-free distilled water with a reproducible
level of TDGP (1).This proceeds from the need to avoid bubble formation when the water is heated or subjected to lowstrength
ultrasonic fields.The use of a simple oxygen sensor (2,3) to provide an estimate of the degree to which distilled water

ABSTRACT
Reliable and predictive in vitro methods to quantify drug transport across the intestinal epithelium are
required at an early stage in the drug development process for oral solid dosage forms. Also,the method should
be useful for evaluating the effects of formulations on the transport. Several approaches have been used to

Abstract
To monitor in vitro drug release in scopolamine transdermal systems,the USP Apparatus 7 was selected.
However,there are very few manufacturers that make USP Apparatus 7. In this article,we studied the in vitro
scopolamine drug release test using a newly designed USP Apparatus 7 from Logan Instruments,Model RRT-

ABSTRACT
The effects of agitation rate,buffer molarity,and mesh size on the dissolution rate of verapamil hydrochloride from sustainedrelease
matrix tablets were studied using USP Apparatus 3. Eudragit® and Carbopol® were used as rate-retarding polymers in
tablets prepared by wet granulation.The study was conducted to determine whether the drugs exhibit similar release characteristics

My dissolution tester failed the USP calibrator tablet test.
What do I do?”
This is a dreaded phone call that every instrument manufacturer
has received at one time or another,perhaps
more than some care to admit. Indeed,what do you do?
First of all,you approach it with a rigorous,systematic
procedure reviewing all critical steps in test set-up and test

This latest textbook in the “Drugs and the Pharmaceutical
Sciences”series aims at providing in-depth information
on injectable suspensions and emulsions,
delivery systems which are becoming more common,in
particular, for biologics,gene therapy,and some small-molecule
low-solubility drugs. Indeed,this 644-page book,
which encompasses all dispersed systems from simple suspensions

Wednesday,November 1,2006,was “Dissolution Day”
at the AAPS Annual Meeting. The day began with a
symposium titled “The Current State of In Vivo–In
Vitro Correlations and Relationships (IVIVC/R) in Pharmaceutical
Technology.” At lunchtime,the Hot Topic was “The Role
of Dissolution in the 21st Century.” In the evening,the AAPS

Abstract
This paper reports on studies of the geometric dimensions and irregularities in the surface of standard 1-L glass dissolution
vessels. Eleven sets of six dissolution vessels from 10 commercial sources were selected for study. A three-dimensional
coordinate measuring machine (CMM) was used to obtain results. The geometric dimensions studied were height,inner