Analysis

ABSTRACT
In the pharmaceutical industry, dissolution testing is a very important tool in drug development and quality control. There
is a need to establish the in vivo performance of products that contain probiotic agents for vaginal administration by
developing in vitro methods of evaluation. In order to achieve a close in vitro–in vivo correlation for a tablet containing a

The effects of selected superdisintegrants on the dissolution behavior of several cationic drugs with varying water
solubility were evaluated. All formulations were made with fixed disintegrant concentration and equal drug load using a
model formulation. Tablets were made by direct compression and were compressed to equal hardness. Dissolution

ABSTRACT
Pharmacopeial Forum 33(3) [May–June 2007] included a Stimuli article titled “Proposed Change to Acceptance Criteria for
Dissolution Performance Verification Testing.” This Stimuli article proposed changing the form of the acceptance criteria
for the Performance Verification Test (PVT) associated with USP Dissolution <711> to make the PVT consistent with the

ABSTRACT
The aim of these studies was to compare dialysis and dispersion methods for determining in vitro release of
propranolol, metoprolol, pindolol, and atenolol from multilamellar liposomes. Multilamellar vesicles (MLV) were prepared
using hydrogenated soy-lecithin phospholipon 90H (Ph 90H) as the primary lipid. The same volume of pH 7.4 phosphate

Q Why can differences be observed between dissolution profiles obtained with water and pH 6.8 phosphate buffer if the pH of both media is almost the same?

I first heard of the upcoming book over two years ago.
Anthony Palmieri, a well-respected professor of
pharmacy, public speaker on dissolution, and inventor
of the Palmieri basket apparatus for dissolution testing of
suppositories, had assembled a dream team of authors.
His goal was to create a new book covering the theory
and methodology of dissolution testing. I reported on

INTRODUCTION
It has become apparent, in the recent past, that vibration
within the tablet dissolution testing environment is
a real issue.
Although this may not have been too apparent in
normal routine dissolution testing, the real impact of
vibration has become a focal point as a result of the
Prednisone “Calibrator Tablet” tests, which generally have

Afiber-optic dissolution testing (FODT) system for solid pharmaceutical formulations has been constructed. The
system is based on a charge-coupled device (CCD) detector and includes six fiber-optic probes. Light is produced
by a small deuterium arc lamp illuminating an optical fiber bundle. Six fiber-optic dipping probes were constructed

Asystematic investigation was performed on the Delphian Rainbow Dissolution Monitor® to fully characterize the
analytical performance of this instrument. The spectra of more than thirty commonly used pharmaceutical
excipient samples were analyzed and grouped into three categories based on their UV absorbance or scattering

The in vitro–in vivo correlation (IVIVC) for a pharmaceutical
product is a mathematical relationship
between an in vitro property of the product and its
in vivo performance. The in vitro release data of the active
substance normally serve as characteristic in vitro
property, while the in vivo performance is represented by
the time course of the plasma concentration of the active