In Vitro–In Vivo Correlation: Importance of Dissolution in IVIVC

Introduction
Correlations between in vitro and in vivo data (IVIVC)
are often used during pharmaceutical development in
order to reduce development time and optimize the
formulation. A good correlation is a tool for predicting in
vivo results based on in vitro data. IVIVC allows dosage form
optimization with the fewest possible trials in man, fixes
dissolution acceptance criteria,and can be used as a surrogate
for further bioequivalence studies; it is also recommended
by regulatory authorities (1–5).

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