Monitoring Ambroxol Hydrochloride Sustained-Release Tablets Release by Fiber-Optic Drug Dissolution In Situ Test System

The purpose of this research was to monitor in situ the drug release of ambroxol hydrochloride sustained-release
tablets using a fiber-optic dissolution test system. A control experiment with a UV-vis spectrophotometer was performed
simultaneously. Within 4 h, a real-time drug release profile was obtained. The average drug release at 60 min, 120 min,
and 240 min was 23.1%, 52.2%, and 87.6%, respectively, using the fiber-optic in situ system. There were no significant
differences between the two methods. The drug release of sustained-release tablets can be monitored by a fiber-optic
drug dissolution in situ test system. Information about the whole dissolution process can be produced by the real-time
dissolution profile.