How statins decrease TG & increase HDL production?

Sponsored Links

Comments

Sravani kompella's picture

Answer: 

Statins inhibit HMGCoA reductase enzyme.This leads to decreased production of apo B containing VLDL particles and upregulation of LDL receptors.chylomicrons and VLDLs are the major Triglyceride trafficking lipoprotiens.Statins that inhibit cholesterol synthesis, will upregulate the most LDL receptors and enhance maximal clearance of the TG-rich VLDLs and chylomicrons. 

Statins increase the HDL-C levels by inhibition of rho-signaling pathways with activation of PPAR-alpha.

http://www.lipidcenter.com/pdf/Statins_and_TG_Reduction.pdf

http://www.medscape.org/viewarticle/479499_5 

Similar Questions

  1. Answers: 1

    Obviously YES.

    Pharma MBA or Management is a good option for career success.

  2. Answers: 1

    hello aishwarya....

  3. Answers: 1
  4. Answers: 1

    It is uric acid.

  5. Answers: 1

    Resp.sir,

    Causes of Rancidity

  6. Answers: 2
  7. Answers: 1
  8. Answers: 1
    Basepairing of D.N.A is.it is ladder like form sugarphosphate of bakbone.i.e