17. Which one of the following is not an example of G protein coupled receptor ?

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Saraswathi.B's picture

Answer: 

Nicotinic cholinergic receptor

Muscarinic acetylcholine receptors, or mAChRs,

Muscarinic acetylcholine receptors are G protein-receptor complexes in the membrane of the cell which are acetylcholine receptors.

acts as the end receptor stimulated by acetylcholine released from parasympathetic nervous system postganglionic fibers.

  • M1 receptor or Muscarinic acetylcholine receptor M1 ------- exocrine glands and CNS

*M2 receptor or Muscarinic acetylcholine receptor M2 ------- heart

*M3 receptor or Muscarinic acetylcholine receptor M3 ----------- smooth muscles, lungs, blood vessels

*M4 receptor or Muscarinic acetylcholine receptor M4 -------------- CNS

*M5 receptor or Muscarinic acetylcholine receptor M5 ------------- location is well known

alpha-1 (a1) adrenergic receptor

alpha-1 (a1) adrenergic receptor is also a GPCR or G protein-coupled receptor . it is associated with the Gq heterotrimeric G-protein.

It consists of three subtypes,

  • a1A adrenergic
  • a1B adrenergic
  • a1D adrenergic

Nicotinic acetylcholine receptors or nAChRs

Nicotinic acetylcholine receptors are the protein neuron receptor. this form ligand-gated ion channels which are the cholinergic receptors in the plasma membrane. and this neurons are on the postsynaptic neuromuscular junction and presynaptic neuromuscular junction.

Nicotinic receptors are of 5 subunits

  • (a1)2v1de (muscle-type),
  • (a3)2(v4)3 (ganglion-type),
  • (a4)2(v2)3 (CNS-type)
  • (a7)5 (another CNS-type).

beta receptor

The adrenergic receptors or adrenoceptors belongs to the class of G protein-coupled receptors. it targets on catecholamines (norepinephrine and epinephrine)

2 subtypes

  • a receptors

*a1 receptor or Alpha-1 adrenergic receptor

*a2 receptor or Alpha-2 adrenergic receptor

*v receptors

*v1 receptor or Beta-1 adrenergic receptor

  • v2 receptor or Beta-2 adrenergic receptor
  • v3 receptor or Beta-3 adrenergic receptor

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