DNA MICROARRAYS TECHNIQUE: APPLICATION IN PHARMACY

Basant Kaushik's picture
Submitted by Basant Kaushik on Wed, 01/14/2009 - 07:26.

Publication Type:

Unpublished

Authors:

Basant Kaushik,Ravindra Gendle,Roshan Patel,Pramod Dewangan,Laxmi Verma,Shekhar Verma

Source:

(2009)

Keywords:

Drug discovery; evidence-based medicine; gene expression; genotyping; pharmacodynamics; transcription profiling

Abstract:

Natural products are gaining increased applications in drug discovery and development. Being chemically diverse they are able to modulate several targets simultaneously in a complex system. Analysis of gene expression becomes necessary for better understanding of molecular mechanisms. Conventional strategies for expression profiling are optimized for single gene analysis. DNA microarrays serve as suitable high throughput tool for simultaneous analysis of multiple genes. Major practical applicability of DNA microarrays remains in DNA mutation and polymorphism analysis. This review highlights applications of DNA microarrays in pharmacodynamics, pharmacogenomics, toxicogenomics and quality control of herbal drugs and extracts