REASONS OF POOR BIOAVAILABILITY
Chronotherapeutic drug delivery systems:
There are several reports indicating that the peformance of a pharmacuetical dosage form is influenced by the changes in suppliers of the same excipient due to the variations in physicochemical properties and quality of excipient. There is increased demand for excipients with pre-determined specifications to control the physical properties of excipients like size, shape, tecture, density and moisture content. Spray dried excipients improves the flow property and freeze dried excipients enhances the dissolution rate.
Pyrogenic -means producing fever (febrile)1
Antibiotics are a particular class of anti-microbials. Anti-microbials is a general term used to cover all class of microbes like bacteria, protozoa, fungi and other such organisms. Antibiotic refers to a drug that is generally used against the infections caused due to bacteria. Starting from the pencilins, cephalosporins and other classes, a number of antibiotics that might be natural, semi-synthetic or synthetic ones are being discovered to fight against different type of infections.
Sterility testing attempts to reveal the presence or absence of viable micro-organisms in a sample number of containers taken from batch of product. Based on results obtained from testing the sample a decision is made as to the sterility of the batch1.
There are two common types of sterility test methods:
PARENTERAL PACKAGING - PLASTIC
Pharmaceutical development of a dosage form will be easier if a system is developed that exactly mimics the conditions of human body. Unfortunately, till date, such a system does not exist. Dissolution serves the
A Polymer consists of repeated subunits of monomers which may or may not be similar in structure1
They may be attached linearly or branched
High molecular weight compounds1
Glass is one of the old and cheapest materials using for the packing of various types of pharmaceutical formuations, especially for the parenteral formulations. It has been used for over 6000 years. Containers for parenteral formulations are made are made as far as possible from the materials that are sufficiently transparent and to permit the visual inspection of the contents.