ajaypalsingh's blog

THE USE OF HEAT IN THERAPY
The application of heat in the treatment of disease was first recorded in the ancient civilizations of Egypt, Greece, and Rome from as early as 2000 BC [1].
Fever is one of the body's own defensive and healing forces, created and sustained for the deliberate purpose of restoring health. The high temperature speeds up metabolism, inhibits the growth of the invading virus or bacteria, and literally burns the enemy with heat. Fever is an effective protective and healing measure not only against colds and simple infections, but against such serious diseases as polio and cancer. In biological clinics, overheating therapies or artificially in the treatment of acute infectious diseases, arthritis and rheumatic disease, skin disorders, insomnia, muscular pain and cancer.

I visited the 10 th International Chemistry Conference and Exhibition in Africa , hosted by Garyounis University , Benghazi (Libya) from 18 th to 21 st November 2007. Theme of this conference is“Recent Advances in Chemistry and Their Applications in Progress of African Countries”. The conference will comprise lectures of invited speakers, oral presentations and poster presentations from professionals working in academic institutions, research institutes and industries from different parts of the world. Research papers in different topics of Chemistry were being presented. About one hundred seventy research papers were selected for presentation in different sessions of the conference. Group discussions on the following topics are being held in the conference:
Technical Sessions
• Analytical Chemistry
• Biochemistry
• Environmental Chemistry
• Inorganic Chemistry
• Industrial Chemistry
• Medicinal Chemistry
• Organic Chemistry

These are some guidelines collected from internet resources, Pharmacists are frequently called on to prepare sterile products intended for ophthalmic administration when a suitable sterile ophthalmic product is not available from a licensed manufacturer. These products may be administered topically or by subconjunctival or intraocular (e.g., intravitreal and intracameral) injection and may be in the form of solutions, suspensions, or ointments. he sterility of these products, as well as accuracy in the calculation and preparation of doses, is of great importance. Ocular infections and loss of vision caused by contamination of extemporaneously prepared ophthalmic products have been reported. Drugs administered by subconjunctival or intraocular injection often have narrow therapeutic indices.

i have found this information during the conference, organized by an industry this claim ganoderma is the king of all adoptogen The word adaptogen, is used by herbalists to refer to a natural herb product that increases the body's resistance to stresses such as trauma, anxiety and bodily fatigue. It is claimed that adaptogenic herbs are unique from other substances in their ability to balance endocrine hormones and the immune system, and they help the body to maintain optimal homeostasis. Adaptogens have a normalizing effect on the body and are capable of either toning down the activity of hyperfunctioning systems or strengthening the activity of hypofunctioning systems. Alleged medicinal uses Ganoderma lucidum may possess some anti-tumor, immunomodulating and immunotherapeutic activities, supported by some studies on polysaccharides, terpenes, and other bioactive compounds isolated from fruiting bodies and mycelia of this fungus.

To establish criteria for the design of controlled release products, a number of variables must be considered mainly

1. Drug properties: The physicochemical properties of a drug, including stability, solubility, partitioning characteristic, charge and protein binding propensity play a dominant role in the design and performance of controlled release system.

2.Route of drug delivery: The area of the body in which drugs will be applied or administered can be restrictive on the basis of technological achievements of a suitable controlled release mechanism or device. Performance of controlled release systems may also be influenced by physiological constraints imposed by the particular route, such as first pass metabolism, gastrointestinal motility, blood supply and sequestration of small foreign particles by the liver and spleen.

The rationale for sustained/ controlled drug delivery is to alter the pharmacokinetic and pharmacodynamic of pharmacologically active moieties by using novel drug delivery systems or by modifying the molecular structure and/ or physiological parameters inherent to a selected route of administration. It is desirable that the duration of drug action become more a design properly of a rate controlled dosage form, and less, or not at all, a property of drug molecule’s inherent kinetic properties. As mentioned earlier, the primary objectives of sustained/controlled drug delivery are to ensure safety and to improve efficacy of drugs as well as patient compliance. This is achieved by better control of plasma drug levels and less frequent dosing.

Tiny remote-controlled tubes may one day let doctors deliver potent drugs to the exact spots in the body they are most needed.
The nanotubes, which are typically about 100 nanometers long, or one ten-millionth of an inch, are made from a special polymer that conducts electricity.
Here's how it's done:
Drug molecules and fibers of a polymer that breaks down in the body are mixed together. The mixture is placed on the tip of a tiny gold electrode, a type of medical probe that can transmit or receive electrical signals.

Elevated intraocular pressure (IOP) is one of the most important risk factors for the development of glaucoma, which is a progressive optic neuropathy. Lowering IOP is currently the only therapeutic approach

The advent of more efficient methods to synthesize and screen new chemical compounds is increasing the number of chemical leads identified in the drug discovery phase. Compounds with good biological

  This guidance was originally published as a part of a proposed implementation document entitled "U.S. FDA's Proposed Implementation of International Conference on Harmonisation (ICH) Safety