3. Microsphere patch
This patch system also contains three layers (i) mucoadhesive layer (ii)a layer of drug loaded microspheres partially immersed in the mucoadhesive layer (iii) an impermeable membrane encompassing microspheres. To fabricate the patches. The microspheres are spread uniformily and partially pressed into a mucoadhesive layer made of Carbopol and pectin which is then covered with an ethyl cellulose layer. A significant enhancement in transport across the intestinal wall is observed in this patch as it provides a high gradient for delivery and the maintenance of unidirectional diffusion towards the intestinal wall.
4. Insulin patch for oral delivery