Metallic nanoparticles in pharmacy
Inorganic metalic nanoparticles have been extensively investigated as contrastive agents in diagnosis and therapeutic purposes . Iron oxide nanoparticles and superparamagnetic iron oxide nanoparticles have been utilised enormously as contrasting agents as they impart darker images of the affected interest regions in case magnetic resonance imaging (MRI). Ambient thermal energy can change the magnetic moment of Iron oxide nanoparticles and this pheneomenon can be widely used for MRI contrast enhancements and tissue-specific moment release for therapeutic drug delivery systems
Superparamagnetic iron oxide (SPIO) nanoparticles can exist either in a form where the core of magnetic nanoparticles is covered with a polymeric coating or in form where a homogeneous distribution is imparted into the matrix of polymeric nanoparticles . This nanoparticular system could be able to exist with a tiny size in the range of 3-6 nm . This system also can deliver different kind of anticancer drugs such as doxorubicin and methotrexate effectively.In addition to these, the gold nanoparticles in combination with the iron oxide nanoparticles are highly effctive to study the MRI contrast agents, and optical probes utilising the properties of reflectance of the gold nanoparticles [19,20].
Fig 4 Different parts of gold nanoparticle layer(20)
19.Ahmad MZ, Akhter S, Jain GK, Rahman M, Pathan SA, Ahmad FJ, Khar RK. Metallic nanoparticles: technology overview & drug delivery applications in oncology.Expert Opin Drug Deliv. 2010 Aug;7(8):927-42. doi:10.1517/17425247.2010.498473.