Effect of L-Dopa, amantadine and tremorine on brain monamines

Submitted by bpsrinivasan on Tue, 05/06/2008 - 16:56.

Publication Type:

Journal Article

Authors:

Seth SD; Srinivasan BP; Siddiqui HH; Sivam SP

Source:

Indian Journal of Pharmacology, Volume 15, Issue 3, p.165-170 (1983)

Keywords:

L-dopa; amantadine; tremorine; serotonin; biogenic amines; behavioural

Abstract:

The effect of L-dopa, alone and in combination, on brain dopamine, norepinephrine, serotonin, 5-hydroxyindole acetic acid and monoamine oxidase activity was investigated in tremorine induced tremor syndrome in rats. L-dopa, alone and in combination with amantadine, produced a remarkable rise in dopamine and 5-hydroxyindole acetic acid and a reduction in serotonin content.Tremorine failed to influence any of the parameters. The findings suggest that L-dopa and amantadine have pro-found effects on brain biogenic amines which may account for the therapeutic effects as well as behavioural side-effects frequently encountered in clinical practice