Investigations into anti-diabetic activity of A. indica

Submitted by bpsrinivasan on Mon, 05/05/2008 - 16:48.

Publication Type:

Journal Article

Authors:

Bajaj S; Srinivasan BP

Source:

Indian Journal of Pharmacology, Volume 31, Issue 2, p.4 (1999)

Keywords:

Diabetes Mellitus/DT; Diabetes Mellitus; Insulin-Dependent; Non-Insulin-Dependent; Rats; Hyperglycemic Agents; Streptozocin/AD; Data Interpretation; Statistical; Animal; Male

Abstract:

Objective:

To investigate the anti-diabetic activity of Azadirachta Indica using IDDM and NIDDM animal models. Methods: Streptozotocin induced models of IDDM (65 mg/kg,iv) as well as NIDDM model (90 mg/kg,i.p in neonates) were given neem leaf extract (NLE, 1 g/kg, po) for 6 weeks and their anti-diabetic activity was assessed.

Result:

The treatment with insulin, aqueous NLE, aqueous NLE with insulin and insulin with aminoguanidine showed a fall in blood glucose levels of 80,45,4,38, 02 and 77-65 percent whereas in NIDDM model, a fall of 53.95 and 60.50 percent were observed with glibenclamide and NLE. Conclusion: Aqueous extract of NLE has a good therapeutic potential as anti-hyperglycaemic agent in IDDM and NIDDM.