Capillary Electrophoresis as a Routine Analytical Tool in Pharmaceutical Analysis

Co-authored by separation scientists at three pharmaceutical companies, this instalment of “CE Currents” describes how these companies have successfully adopted capillary electrophoresis for routine analysis. The column discusses using capillary electrophoresis to support aspects of early drug discovery testing, to analyse protein-based pharmaceuticals, and to support drug development and routine quality control of marketed pharmaceuticals.

This “CE Currents” column examines the use of capillary electrophoresis (CE) in three important areas of pharmaceutical analysis. The first section deals with using CE to support aspects of early drug discovery testing, and it uses examples from Cardiome Pharma Corp. (Vancouver, British Columbia, Canada). The second section concentrates on using CE to analyse protein-based pharmaceuticals, a fastgrowing area, and it incorporates several examples from Genentech Inc. (South San Francisco, California, USA) and other biotechnology companies. The last section provides details about using CE for supporting drug development and routine quality control of marketed pharmaceuticals, and it focuses on methods used within GlaxoSmithKline R&D (Ware, UK).

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