Isolator Decontamination Using Chlorine Dioxide Gas

The use of isolation technology in the United States and Europe is beginning to show signs of widespread acceptance and growth.With the increased use of isolators for critical processes comes a demand for better and quicker decontamination methods. Fueling the growth of chlorine dioxide (CD) in the pharmaceutical and medical device industries are its properties as a true gas at ambient temperatures, its capacity to be unaffected by temperature variations and gradients, and its tight process consistency because concentrations can be precisely monitored and controlled. CD properties and background CD is a single-electron, transfer-oxidizing agent. The gas has a chlorine-like odor and a green–yellow color, which enables it to be monitored with an ultraviolet (UV)–vis spectrophotometer. This monitoring can help provide tight process control of the decontamination cycle from beginning to end.

View Full Article