Chemistry Articles

Amorphous systems have attracted considerable attention due to their favorable properties; however, their stability issues still pose a major challenge. The purpose of the present work was to investigate the role of molecular mobility and moisture in the physical stability of a selected pharmaceutical amorphous system.

Abstract

The present investigation describes the design and development of self-correcting monolithic Gastroretentive system of baclofen. Tablets were prepared by direct compression method. Optimization was carried out using simplex lattice design.

N-Acetylcysteine was known to be used as a mucolytic agent having significant antioxidant activity. It has been reported to be used to alleviate or improve various cosmetic conditions and dermatological disorders including changes or damage to skin associated with intrinsic or extrinsic aging recently.

The probiotic formulations are susceptible to loss in viability due to formulation, processing, storage and in vivo environment. The aim of the present study was to perform preformulation studies of probiotic Bacillus coagulans spores to aid designing of stable formulations.

The aqueous extract of Swertia chirata Buch Ham. Root (ASC) (Family: Gentianaceae) was evaluated for its antipyretic potential on Brewer’s yeast-induced pyrexia in albino rats and Typhoid-Paratyphoid A, B vaccine induced Hyperexia in rabbits. In both models, the extract, at dose of 200 mg kg−1 body wt.

Knowledge about therapy with insects in Mongolian traditional medicine is less studied even they have been used broadly since ancient time. Several orthodox practitioners have surveyed the therapeutic potentials of defensive agents in Blaps femoralis known as “stink beetle” in the past.

In the present study the significant role of the α,β-unsaturated carbonyl structure in the anti-inflammatory activity of the natural humulane sesqui-terpenoids zerumbone and zerumbone 2,3-epoxide was evidenced from a comparative study of the ability of zerumbone and zerumbone 2,3-epoxide to inhibit NF-κB activation and NO production in LPS (lipopolysaccharide)- stimulated RAW 264.7 cells.

During the process development of Salmeterol, an unknown impurity was detected at 2.08 Relative Retention Time (RRT) at a level of 0.11% by a gradient Reverse Phase-High Performance Liquid Chromatography (RP-HPLC). The impurity was isolated from the salmeterol drug substance using preparative HPLC.

55Co](III)[APTS]2) was investigated. Co-55 (T1/2=17.53 h) was produced by 150 μA irradiation of a natural nickel target by 15 MeV protons. The 55Co was separated from the irradiated target material using a two-step method with a radiochemical yield of >95% followed by radionuclidic and chemical purity control.