Crystal Structure of Fucose-Specific Lectin from Aleuria aurantia Binding Ligand

Lectins are sugar-binding proteins, some of which have great value as specific probes for investigating the structure and function of carbohydrate chains o­n glycoproteins and glycolipids. Many kinds of lectins are found in plants, animals, and fungi; more than 200 crystal structures have been determined. These structures are classified into various folding families, such as legume lectin folding, C-type lectin, I-type lectin, P-type lectin, -prism I and II, -trefoil, five--propeller folding, etc. Most of these families contain several -strands in the core structure. The most widely observed folding is the legume lectin folding which consists of a two-layered -sheet structure termed the jellyroll motif.

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