Discovery of a Simple Picomolar Inhibitor of Cholesteryl Ester Transfer Protein

Emily J. Reinhard, Jane L. Wang, Richard C. Durley, Yvette M. Fobian, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, Michele CETP is a plasma glycoprotein that mediates the transfer of neutral lipids among various plasma lipoproteins. CETP facilitates the transfer of cholesteryl ester (CE) from high-density lipoprotein (HDL) to apolipoprotein B-containing lipoproteins such as very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) with a balanced exchange of triglyceride (TG).

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