Inositol Pyrophosphates Are Required for DNA Hyperrecombination in Protein Kinas

Inositol 1,4,5-trisphosphate (InsP3), a major second messenger for multiple intercellular messengers, triggers the release of intracellular calcium. A variety of higher inositol polyphosphates exist including the recently discovered pyrophosphates diphosphoinositol pentakisphosphate (InsP7)1 and bis-diphosphoinositol tetrakisphosphate (InsP8) which contain energetic pyrophosphate bonds.

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