Local Protein Dynamics and Catalysis: Detection of Segmental Motion Associated

The glutathione transferases (EC 2.5.1.18) catalyze the addition of glutathione (GSH) to both endogenous and xenobiotic electrophilic compounds. They are perhaps the single most important group of enzymes for initiating the metabolism and disposition of potentially toxic alkylating agents. The canonical GSH transferase superfamily consists of at least nine subfamilies.

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