Role of the Large Cytoplasmic Loop of the 7 Neuronal Nicotinic Acetylcholine

Neuronal nicotinic acetylcholine receptors (nAChR) are members of a supergene family of ion channels gated by neurotransmitters. They are pentameric oligomers composed of related glycoprotein subunits, each o­ne composed of ~500 amino acids and four transmembrane segments. About 210 amino acids at the N-terminus form the major extracellular domain.

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