Structure of Subtilosin A, a Cyclic Antimicrobial Peptide from Bacillus subtilis

Bacteriocins are potent antimicrobial peptides that are ribosomally produced by bacteria, and many are useful food preservatives. These peptides are generally cationic, range from 25 to 60 amino acids in length, and can be primarily divided into two major classes: unmodified peptides (except for disulfide bridges) and lantibiotics. The latter are extensively posttranslationally modified by enzymatic dehydration of serine or threonine residues to give dehydroalanine or dehydrobutane moieties, which may form monosulfide lanthionine bridges through Michael attack at the position by proximal cysteine residues.

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