The 2.1 E Structure of Torpedo californica Creatine Kinase Complexed

Creatine kinase (CK, EC 2.7.3.2), a member of the guanidino kinase superfamily, catalyzes the reversible phosphorylation of creatine (Cr), transferring the phosphate group from ATP-Mg2+ and forming phosphocreatine (PCr) and ADP-Mg2+. Phosphorylated guanidino compounds (phosphagens), such as phosphocreatine (PCr), are considered to be reservoirs of "high-energy phosphate" which are able to supply ATP o­n demand. Consequently, CK plays a significant role in energy homeostasis in cells with intermittently high energy requirements, by shuttling energy between different cellular compartments. As may be expected for an enzyme playing such a crucial role in energy homeostasis, CK is a highly conserved enzyme with a sequence that is ~60% identical across all species.

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