Wewakazole, a Novel Cyclic Dodecapeptide from a Papua New Guinea Lyngbya majuscu

Lyngbya majuscula is best recognized for its production of lipopeptides, products of both polyketide synthase (PKS) and nonribosomal polypeptide synthetase (NRPS) biosynthetic origins. In fact, natural products of purely amino acid derivation are comparatively rare from this genus. A phytochemical study of a Papua New Guinea collection of this cyanobacterium resulted in the discovery of wewakazole, a cyclic peptide integrating structural features uncharacteristic of L. majuscula secondary metabolites. In this paper, we present the isolation and structure determination of this novel marine cyanobacterial metabolite.

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