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Preparative Chiral SFC as a Green Technology for Rapid Access to Enantiopurity in Pharmaceutical Pro

Recently, the subject of “green chemistry” has received considerable attention from academic and industrial researchers alike . While the central tenets of waste reduction, pro c e s s economy, and elimination of risks and haza rds have long been embraced by industrial p rocess chemists, the current focus on gre e n chemistry concerns has led to re n ewed a p p reciation for the importance of these topics. The analysis of the “greenness” of any given process, operation, or methodology is a useful exe rcise that can lead to p rocess improvement and refinements. This e xe rcise can be particularly valuable for new technologies that might not yet have a long track record of practical utilization.

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Author(s): 
Christopher J. Welch, William R. Leonard Jr., Jimmy O. DaSilva, Mirlinda Biba, Jennifer Albaneze-Walker, Derek W. Henderson, Brian Laing, David J. M a t h re
Journal: 
LCGC North America, Jan 1, 2005
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