Design and Development of Topical Microemulsion for Poorly Water-Soluble Antifungal Agents

in Clinical and Experimental Therapeutics Most pharmaceutical drug substances are lipophilic compounds, which are practically insoluble in water. Researchers have developed drug delivery systems, such as tablets, capsules, ointments, creams, gels, suspensions, solutions, and emulsions, in many dosage forms to deliver these lipophilic substances to patients. A microemulsion,1–5 o­ne of the pharmaceutical interests for new drug delivery, is normally composed of oil, water, surfactant, and cosurfactant. Hoar and Schulman6 were the first to introduce the word microemulsion, which they defined as a transparent solution obtained by titrating a normal coarse emulsion with medium-chain alcohols. The short to medium-chain alcohols are generally considered as cosurfactants in the microemulsion system.



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