Skin is the largest organ of the human body, and its complex and sensitive nature toward various foreign and internal factors makes it highly susceptible to a number of diseases and disorders. The result of these foreign and internal factors (environmental, physical, microbial, hormonal, and others) is critical conditions and related symptoms. The number of patients recruited for major indications from 2000 to 2010. Pharmaceutical companies conduct clinical trials based on factors such as a promising therapeutic area, unmet needs for a particular indication, and the presence of a significant patient population. Currently, there are many indications for which no appropriate treatment is available. Therefore, pharmaceutical companies are currently analyzing the potential of launching new therapies and tapping the potential market.