Choosing between placing a sizable bet on metrics to predict successful investigative site performance versus on implementing practices to support site performance success, most sponsors and CROs would choose the former. Ideally, both approaches play an important role. But most sponsors and CROs are investing in the former approach without much to show for it. Perhaps it's time that more sponsors and CROs focused attention on the latter? Under tighter budgets and timelines, a number of pharmaceutical and biotechnology companies and CROs have been analyzing reams of descriptive and historical performance data supplied by investigative sites and maintained in house to identify factors that better predict successful patient enrollment. Four factors have emerged as promising predictors: past performance, experience, investigative site focus, and historic speed to randomize the first study volunteer.
Applied Clinical Trials, Nov 1, 2011