new chemical entity often is first formulated as a free-flowing granulation for encapsulation within hard gelatin capsules. During the course of clinical development, the drugcontaining granulation usually is modified for compaction into a tablet product. The tablet product subsequently may be film coated for taste masking, identification, or other purposes. Tablets are the most preferred and widely used dosage form because of their ease of administration, lower cost of manufacture, and elegance. In this article, we describe a means of producing tablet dosage forms (specifically, compression-coated tablets) from granulations or blends that do not readily form a compact. The compression-coating granulation or blend can be preformulated to provide desired functionalities to the coating. The o­nly requirement for producing the compression-coated tablet dosage form described herein is that the core material should possess the ability to flow into a die during

For full article Click Here