Aqueous-based film coating has become a very popular method for applying a polymeric film to solid substrates to modify drug release from tablets and beads. The number of polymers and formulations of polymers that provide the desired properties of adhesion, toughness, and permeation properties in aqueous film coating applications has rapidly increased during the past few years. A typical film coating formulation will contain a polymer, plasticizer, anti-adherent, and a pigment or opacifier in either a solvent or aqueous vehicle. Polymer-pigment interactions in aqueous film coating was the subject of a recent article by Nyamweya et al. Environmental and toxicological concerns associated with organic solvent-based coating have resulted in many regulatory restrictions that have accelerated the transition to aqueous-based coating systems. Polymeric film coatings may be divided into different classifications depending upon their solubility, permeability, and disintegration properties. The influence of formulation factors o­n the stability and performance of film-coated dosage forms has been extensively studied by numerous researchers.


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