Anti-Microbial Activity of Gum Karaya: Emerging Pharmaceutical Excipient

Prof. K.V. RAMANA MURTHY's picture
Submitted by Prof. K.V. RAMA... on Thu, 05/15/2008 - 20:24

Publication Type:

Journal Article

Authors:

G. V. Murali Mohan Babu; Thaer Abdel Ghani; N. Ravi Kumar; P. Ellaiah; K. V. Ramana Murthy

Source:

Indian Drugs, Volume 38, Issue 153 (2001)

Keywords:

Anti-Microbial Activity, Emerging Pharmaceutical Excipient, Gum Karaya

Abstract:

A study was undertaken to find out the viscosity changes of aqueous solution of an emerging pharmaceutical excipient Gum karaya (GK) and modified form of GK (mGK) in comparison with that of guar gum (GG) on long-term storage. It was found that GK and mGK showed no significant changes in their respective viscosities. However, the viscosities of GG aqueous solutions were significantly decreased on long-term storage. Viable count and anti-microbial activity studies confirmed the antimicrial activity of GK and mGK. Aqueous solution of GK exhibited high~st anti-microbial activity and low viable count among the studied excipients. The order of anti-microbial activity is GK>mGK>GG.