Studies on the Solid Dispersion Systems of Glipizide

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Abstract:

Solid dispersions of glipizide were prepared using water-soluble carriers such as polyvinylpyrrolidone and polyethylene glycol by common solvent method in an attempt to increase the dissolution rate of glipizide, a practically insoluble drug in water. Differential scanning calorimetry, x-ray difiractometry and in vitro dissolution studies were used to characterize the solid dispersions. No chemical interaction was found between glipizide and polyvinylpyrrolidone/polyethylene glycol. The results from Differential scanning calorimetry and x-ray diffractometry studies show that polyvinylpyrrolidone/polyethylene glycol inhibits the crystallization of glipizide. The solid dispersions prepared in this study were found to have higher dissolution rates compared to intact glipizide and physical mixtures of polyvinylpyrrolidone/polyethylene glycol and glipizide. It was found that the optimum weight ratio for glipizide:carrier is 1:5 for polyvinylpyrrolidone and 1:7 for polyethylene glycol.