Drug Development Articles

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Purpose: To develop a simple, cheap, fast, accurate, sensitive and precise colorimetric method that can be used for the determination of chloramphenicol.

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Purpose: To identify the dispensing procedure at a pharmacy, investigate the possible operational problems that may lead to excessive patient waiting times as prescriptions are filled and to examine patient disposition to perceived delays at the pharmacy.

In this note we describe a modification of the sequential probability ratio test (SPRT) developed for the purpose of “flagging” a significant increase in the mortality rate of a treatment relative to a control while ensuring that double-blinding and the Type I error for the primary test of efficacy, also based on mortality rates, is not compromised.

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Purpose: Alkyd resins constitute a very high proportion of conventional binders used in surface coatings. In order to enhance the quality of these alkyd resins methyl esters of rubber seed oil (MERSO) were used in the preparation of the resins.

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Purpose: The root and aerial parts of Boerhaavia diffusa Linn. (Nyctaginaceae) were used in Ayurveda for the treatment of diabetes. The present study is aimed at evaluating the antidiabetic activity of chloroform extract of Boerhaavia diffusa leaves on chronic administration in streptozotocin-induced non-insulin-dependent diabetes mellitus (NIDDM) model diabetic rats.

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Purpose: To compare the awareness and treatment knowledge of malaria amongst caregivers of young children in urban and rural areas of Ado-Odo/Ota Local Government Area in Ogun State.

Method: Structured questionnaires were administered to caregivers of children under the age of five years in 1472 households using a multistage random sampling technique.

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Purpose: There is the need for alternative and more convenient route of quinine (QN) administration in complicated and severe malaria. The purpose of this study is to compare the bioavailability (BA) of a new quinine suppository made from theobroma oil to that of an existing tablet formulation in healthy volunteers.

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Purpose: The individual and interaction effects of formulation variables on the release of suppositories were investigated using a 23 factorial experimental design. The variables studied were nature of base (B), type of drug (D), and presence of surfactant (S).

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Purpose: Some excipients are currently available for the formulation of pharmaceutical suspensions. The purpose of this study is to search for a cheap and effective natural excipient that can be used as an effective alternative for the formulation of pharmaceutical suspensions.