To be sure, the road to clinical trials transparency is paved with good intentions—from the architects of http://www.clinicaltrials.gov//, to the sponsors, to the "external" stakeholders. But this road is proving to be a difficult one to travel.
Drug Development Articles
Purpose: The purpose of the present research was to the effect of camphor as a subliming agent on the mouth dissolving property of famotidine tablets.
Purpose: The study was carried out to evaluate the quality of artesunate tablets sold in retail and wholesale pharmacies in Kumasi, Ghana. In particular, the study sought to ascertain the presence or otherwise of counterfeit artesunate tablets in Kumasi.
Purpose: To assess the microbiological quality of some milk products in Abuja, Nigeria capital city; and the resistance of isolates to some broad spectrum antibiotics.
Purpose: Concurrent use of orthodox and herbal medicines is likely to precipitate an overall effect which may or may not be beneficial to the patient. The objective of this study was to evaluate the antimicrobial interaction between the methanol extract of Garcinia kola seed (GKS) which is chewed habitually as a masticatory in many rural communities in Africa and gatifloxacin (GAT), a fourth generation fluoroquinolone.
Purpose: In the present study, six flavonoids (5,7-dimethoxyflavanone-4’-O-β-D-glucopyranoside, 5,7-dimethoxyflavanone-4’-O-[2’’-O-(5’’’-O-trans-cinnamoyl)-β-D-apiofuranosyl]-β-D-glucopyranoside, naringenin-7-O-β-D-glucopyranoside, 5,7,3’-trihydroxy-flavanone-4’-O-β-D-glucopyranoside, rutin, and nicotiflorin) isolated from Galium fissurense, Viscum album ssp.
Purpose: The purpose of the study is to evaluate the antimicrobial and antitumor activities of Stevia rebaudiana (Asteraceae) leaf extracts.
Purpose: Among the Hausas of Northern Nigeria, it is claimed by local (traditional) healers that the infusion of C. occidentalis leaves is used as a cure for hepatitis. This study was designed to evaluate the possible negative effects of the aqueous extract of this herb on serum total proteins, albumin, bilirubin, alanine amino transferase (ALT), aspartate amino transferase (AST) and alkaline phosphatase (ALP), as part of a larger study undertaken by these authors to ascertain the hepatoprotective potential of the plant extract.
Purpose: Boswellia serrata, a common medicinal plant, has multiple uses in traditional medicine and, in particular, for the treatment of inflammatory diseases. The plant and its extracts have been evaluated for a number of activities, namely, anti-inflammatory, analgesic, anti-arthritic and antipyretic. In this study, the plant was subjected to genotoxicity studies in order to ascertain an aspect of the safety of the drug.
Purpose: The aim of this study was to evaluate the efficacy of combined local corticosteroid and anaestethic therapy with home exercise programme in the treatment of painful shoulder conditions.
Purpose: The main objective of this study was to measure serum complement C3 and C4 concentrations in patients of lupus nephritis to see if these simple measurements would give useful information to the clinician managing such patients..
Purpose: The aim of our present work is to develop a simple steady state model for intraretinal oxygen partial pressure distribution and to investigate the effect of various model parameters on the partial pressure distribution under adapted conditions of light and darkness..
Phenolic compounds form one of the main classes of secondary metabolites. They display a large range of structures and are responsible for the major organoleptic characteristics of plant-derived foods and beverages, particularly color and taste properties. They also contribute to the nutritional qualities of fruits and vegetables. Among these compounds, flavonoids constitute one of the most ubiquitous groups of plant phenolics.
Chitosan is a natural polycationic copolymer consisting of glucosamine and N-acetylglucosamine units. The polymer has valuable properties as a biomaterial because it is considered to be biocompatible, biodegradable and non-toxic. The purpose of this review article is to provide detailed information about thiolated chitosans which are gaining popularity because of their high mucoadhsiveness and extended drug release properties. The derivatization of the primary amino groups of chitosan with coupling reagents bearing thiol functions leads to the formation of thiolated chitosans.
Pharmaceutical invention and research are increasingly focusing on delivery systems which enhance desirable therapeutic objectives while minimising side effects. Recent trends indicate that multiparticulate drug delivery systems are especially suitable for achieving controlled or delayed release oral formulations with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time.
Controlled release (CR) dosage forms have been extensively used to improve therapy with several important drugs. However, the development processes are faced with several physiological difficulties such as the inability to restrain and localize the system within the desired region of the gastrointestinal tract and the highly variable nature of the gastric emptying process. This variability may lead to unpredictable bioavailability and times to achieve peak plasma levels.
Purpose: The ethanol extracts obtained from the leaves, rootstock and the combined formulation of endemic Salvia tigrina Hedge & Hub.-Mor. (Labiatea) have been investigated for their antifungal activities.
Purpose: To characterize the microorganisms influencing greenhouse evaporative cooling system fouling as a prelude to designing a sustainable remediation scheme that would assist in reducing the heavy financial loss incurred by stakeholders due to deterioration of cooling pads.
Purpose: The aim of the work was to prepare nitrendipne-loaded Eudragit RL 100 microspheres to achieve sustained release nitrendipine.
Purpose: This paper was mainly aimed to investigate drug resistance of the various urinary tract infection (UTI) pathogens from patients of different gender and age groups of Pakistanis.
Purpose: Oxidative stress has been shown to play an important role in the development of anaemia in malaria. Indeed, increase in total antioxidant status has been shown to be important in recovery from malaria. The antioxidant activities of four medicinal plants traditionally used in the treatment of malaria in southwestern Nigeria were determined.
Purpose: The widespread use of non-steroidal anti-inflammatory drugs (NSAID) has meant that the adverse effects of these relatively safe drugs have become increasingly prevalent. This work examines the pattern of sale and use of NSAIDs as to call for caution in cases of misuse that may lead to renal, gastrointestinal and cardiac damage in users.
Purpose: The effects of treating the tapioca (the fibrous residue obtained after up to 90% of the proportion of starch has been removed from the peeled and rasped roots of cassava tubers powder with dilute solutions of hydrochloric acid) in order to find an approach for rendering an otherwise poorly compressible material to a directly compressible powder.
Purpose: Although snake bites occur frequently in Benin City, the prevalence has not been documented. This study was therefore done to determine the prevalence, morbidity, mortality, and the orthodox treatment of victims.