Drug Development Articles

Drug Development related full text articles from Pharmaceutical Journals

Antimicrobial Activity of Tamarindus indica Linn

Abstract

Author(s): 
JH Doughari
Journal: 
Tropical Journal of Pharmaceutical Research 2006; 5(2): 597-603

Compression, Mechanical and Release Properties of Chloroquine Phosphate Tablets containing corn and Trifoliate Yam Starches as B

Purpose: A study was made of the binding properties of trifoliate yam starch, obtained from Dioscorea dumetorum (Pax), in chloroquine phosphate tablet formulations in comparison with official corn starch.

Author(s): 
Oladapo A. Adetunji, Michael A. Odeniyi and Oludele A. Itiola
Journal: 
Tropical Journal of Pharmaceutical Research 2006; 5(2): 589-596

Effect of Solvent Type and Drying Method on Protein Retention in Chitosan-Alginate Microcapsules

Purpose: The effect of solvent used in dissolving chitosan (membrane material) and the microcapsule drying method used, on protein retention in chitosan-alginate microcapsules were studied since these factors affect the physicochemical characteristics of the coating membrane.

Author(s): 
Edith I Ahonkhai, Ikhuoria M Arhewoh and Augustine O Okhamafe
Journal: 
Tropical Journal of Pharmaceutical Research 2006; 5(2): 583-588

In vitro Antimicrobial Activity of the Extract of Mitracarpus scaber Leaves Formulated as Syrup

Abstract

Purpose: To formulate the crude extract of the leaves of Mitracarpus scarber “Zucc” as a syrup.

Author(s): 
TA Abere, AO Onyekweli, and GC Ukoh
Journal: 
Tropical Journal of Pharmaceutical Research 2007; 6(1): 679-682

Effects of Coadministration of Extract of Carica papaya Linn (family Cariaceae) on Activity of Two Oral Hypoglycemic Agents

Abstract

Purpose: To investigate the interacting effects of co-administration of Carica papaya leaf extract on the hypoglycemic activity of metformin and glimepiride in an animal model.

Author(s): 
TO Fakeye, T Oladipupo, O Showande and Y Ogunremi
Journal: 
Tropical Journal of Pharmaceutical Research 2007; 6(1): 671-678

Evaluation of Pharmaceutical and Microbial Qualities of Some Herbal Medicinal Products in South Western Nigeria

Abstract

Purpose: The aim of the present study was to investigate the pharmaceutical and microbial qualities of 21 different (of various dosage forms) Herbal Medicinal Products (HMPs) sourced from some traditional medicine sales outlets and retail pharmacy outlets in south western Nigeria.

Author(s): 
Adenike Okunlola, Babatunde A. Adewoyin and Oluwatoyin A. Odeku
Journal: 
Tropical Journal of Pharmaceutical Research 2007; 6(1): 661-670

Formulation of Sodium Alginate Nanospheres Containing Amphotericin B for the Treatment of Systemic Candidiasis

Abstract

Purpose: The aim of this work was to formulate sodium alginate nanospheres of amphotericin B by controlled gellification method and to evaluate the role of the nanospheres as a “passive carrier” in targeted antifungal therapy.

Author(s): 
Shanmugasundaram Sangeetha*, Dhandapani Nagasamy Venkatesh, Rajendran Adhiyaman, Kumaraswamy Santhi, and Bhojraj Suresh
Journal: 
Tropical Journal of Pharmaceutical Research 2007; 6(1): 653-659

A Comparative Evaluation of the Flow and Compaction Characteristics of a-Cellulose obtained from Waste Paper

Abstract

Purpose: Alpha-cellulose obtained as pulp from fibrous plant materials has found use in the pharmaceutical industry as a disintegrant and direct compression diluent. The aim of this study was to evaluate the suitability of α-cellulose obtained from waste paper as a direct compression excipient.

Author(s): 
FO Ohwoavworhua, TA Adelakun and OO Kunle
Journal: 
Tropical Journal of Pharmaceutical Research 2007; 6(1): 645-651

Modified Transdermal Technologies: Breaking the Barriers of Drug Permeation via the Skin

Transdermal drug technology specialists are continuing to search for new methods that can effectively and painlessly deliver larger molecules in therapeutic quantities to overcome the difficulties associated with the oral route, namely poor bioavailability due to hepatic metabolism (first pass) and the tendency to produce rapid blood level spikes (both high and low).

Author(s): 
Ritesh Kumar and Anil Philip
Journal: 
Tropical Journal of Pharmaceutical Research 2007; 6(1): 633-644

Evaluation of Phytochemical Constituents, Antibacterial Activities and Effect of Exudate of Pycanthus Angolensis Weld Warb (Myri

Purpose: A 1: 1: 2 mixture of exudates of Anchomonas difformis, Cyrtrospherma senegalense and Pycanthus angolensis is claimed to be used for the treatment of corneal ulcers.

Author(s): 
DN Onwukaeme, TB Ikuegbvweha, and CC Asonye
Journal: 
Tropical Journal of Pharmaceutical Research 2007; 6(2): 725-730
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