Performance Qualification of LC Systems

Chromatographers can use a simple set of tests to check system performance.

Users of liquid chromatography (LC) systems have two compelling reasons to ensure that their systems are working properly. First, good science — why would anyone want to perform LC experiments on a system that isn’t working at its best? Second, the government regulations for the laboratory environments in which many analysts work require testing to confirm that the instruments are doing their jobs. One of the most common series of tests is the installation, operational and performance qualification tests familiar to most laboratory workers. Installation and operational qualification are generally performed by the vendor when a new system is installed. Performance qualification — a periodic test that ensures that an instrument operates as specified — is often the responsibility of users.


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