The Effect of Spray-Drying Feed Temperature and Subsequent Crystallization Condi

Spray-drying is known to produce predominantly amorphous material because of rapid solidification.1 The detection and control of the amorphous portion of powdered material is of utmost importance, as different physical forms of materials have different physicochemical properties that give rise to significant differences in functionality when used in dosage forms. The influence of spray-drier feed concentration o­n the degree of crystallinity and the crystal form of lactose (β-lactose, anhydrous α-lactose, α-lactose monohydrate) has been described previously.2It is known2 that the spray-drying process can be made to produce completely amorphous lactose particles. Furthermore, it is clear that the amorphous form is unstable and that it will revert to the crystalline form. In this work, the impact of feed temperature variation and the conditions used to induce crystallization have been investigated, with respect to the physical form that is produced.


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