A Closer Look at Automated In-Line Dilution

Automated in-line dilution is an increasingly popular technology in the biopharmaceutical industry. In-line dilution is a process that can help solve capacity, financial, and quality concerns that biopharmaceutical manufacturing plants may be facing regarding process solution preparation and delivery. This technology has several applications in biopharmaceutical manufacturing, such as purification processes, chromatography systems, solvent adjustment, pH adjustment, and cleaning systems. The fundamental aspects of automated in-process dilution systems are discussed, including engineering considerations, equipment components, process materials, operation, maintenance, and quality considerations.