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Formulation and Process Development Articles

Determination of Letrozole in Tablet Formulations by Reversed Phase High Performance Liquid Chromatography

Purpose: To develop a simple, rapid, accurate and cost-effective reversed phase high performance liquid chromatography (RP-HPLC) method for letrozole in bulk and in tablets. Methods: Development of a method for the determination of letrozole, an anti-cancer drug, by RP-HPLC was undertaken using a new mobile phase of acetonitrile:water (50:50, v/v). The eluent was monitored at 265 nm.
Journal: 
Trop J Pharm Res, October 2010; 9(5)
Articles: 

In Vitro Anticholinesterase and Inhibitory Effects of the Aqueous Extract of Combretum molle (Combre-taceae) Leaf on Rabbit Breathing

Purpose: In previous studies, the aqueous extract of Combretum molle was shown to inhibit disturbances of breathing induced by acetylcholine. The aim of this study was to elucidate the mechanism of this inhibition.
Journal: 
Trop J Pharm Res, October 2010; 9(5)
Articles: 

Acute and Sub-chronic (28-day) Oral Toxicity Studies of Hydroalcohol Leaf Extract of Ageratum conyzoides L (Asteraceae)

Purpose: Ageratum conyzoides is an annual herbaceous plant commonly used in African traditional medicine as a purgative, antipyretic, anti-ulcer and wound dressing agent. The objective of this study was to investigate the acute and sub-chronic toxicity of A. conyzoides leaves in Wistar rats.
Journal: 
Trop J Pharm Res, October 2010; 9(5)
Articles: 

Immunomodulatory Activity of the Methanol Extract of Amorphophallus campanulatus (Araceae) Tuber

Purpose: Traditionally, Amorphophallus campanulatus tuber is used for the treatment of enlarged spleen, rheumatism and tumour. Therefore, this study was designed to evaluate the immunomodulatory activity of the plant material.
Journal: 
Trop J Pharm Res, October 2010; 9(5)
Articles: 

Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphism: An Observational Study among Diabetic Hypertensive Subjects in Malaysia

Purpose: This study investigated the influence of angiotensin-1 converting enzyme (ACE) insertion-deletion (ID) gene polymorphism on the treatment responses of type 2 diabetic subjects at varying stages of nephropathy to ACE inhibitors (ACEI) with regard to blood pressure (MAP) and renal response (GFR).
Journal: 
Trop J Pharm Res, October 2010; 9(5)
Articles: 

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