Formulation and Process Development Articles

Purpose:“Skin care” refers to the general concept of maintaining the homeostasis of the skin. Ceramide, the main lipid constituent of the stratum corneum, is important in maintaining the barrier function of the skin. In this study, skin care formulation containing ceramide was prepared and evaluated the effectiveness for skin treatment.

Purpose:To prepare oleanolic acid hemiphthalate disodium (OAHPDS)-hydroxypropylmethyl-cellulose acetate succinate (HPMCAS) microspheres and investigate their in vitro properties. Methods: The OAHPDS-HPMCAS microspheres were prepared by the emulsion-solvent evaporation method, and the in vitro drug release profiles of the microspheres were determined.

Purpose:To test the anti-tumor efficacy of doxorubicin (Dox) in combination with IFN-γ on Hepatocarcinoma 22 (H22) cells in vitro and in vivo. Methods: 50% inhibition concentration (IC50) of Dox with or without IFN-γ pretreatment was firstly determined in vitro.

Purpose: To characterize and investigate the in-vitro drug release behavior of a chitosan-magnesium stearate monolithic system. Methods: A monolithic system consisting of chitosan and magnesium stearate was prepared by direct compression to provide sustained release of propranolol HCl in a pH change system.

Ganciclovir (GCV) is a nucleoside analogue of guanosine that exhibits antiviral activity against viruses of the herpes group, including cytomegalovirus. GCV is an effective therapy for cytomegalovirus infection in immunocompromised patients, such as patients with acquired immunodeficiency syndrome or those with immunosuppressive therapy following organ transplantation.

As a consequence of modern drug discovery techniques, there has been a steady increase in the number of new pharmacologically active lipophilic compounds that are poorly water-soluble. It is a great challenge for pharmaceutical scientists to convert those molecules into orally administered formulations with sufficient bioavailability.

Purpose:To study the in vitro metabolism of CPU0213 in rat liver microsomes, and explore changes in the metabolism of CPU0213 by CYP450 3A under oxidative stress.

Purpose:  To evaluate the pharmacokinetics and bioequivalence of bismuth from two compound preparations. Methods: This was an open randomized, two period cross-over study on twenty healthy male volunteers.

Purpose:This study was carried out to examine the effect of different types of micelles on the UV absorption and acid-base dissociation of indicators and to use that information for the CMC determination of surfactants at various pH values.

Purpose:To establish a method for preparing protein microspheres for oral administration. Methods: Using bovine serum albumin (BSA) as a model protein and alginate and chitosan as carrier materials, BSA loaded alginate/chitosan microspheres were prepared by a modified emulsifying-gelatinization method.