Formulation and Process Development Articles

Purpose: To investigate the use of cationic biosurfactant-containing liposomes as a delivery system of siRNA to cancer cells. Methods: Cationic 1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (EDOPC)-based liposomes were formulated with various amounts of a biosurfactant, surfactin, ranging from 3 to 14 mole%.

Purpose:To study the electrochemical behavior and catalysis mechanism for dopamine and ascorbic using an activated roughened glassy carbon electrode, and to develop a sensitive and selective method for the determination of dopamine and ascorbic acid. Methods:The activated roughened glassy carbon electrode was prepared by potential recycling in a 0.2 mol/l aqueous solution of NaOH.

Purpose:Most eye diseases are treated with topical application of eye drops. The poor bioavailability and therapeutic response exhibited by these conventional eye drops due to rapid precorneal elimination of the drug may be overcome by the use of in situ gelling systems that are instilled as drops into the eye and undergo a sol-to-gel transition in the cul-de-sac.

Purpose:To develop a suitable ratio of n-6 to n-3 polyunsaturated fatty acid (PUFAs) emulsions for intravenous injection containing sea buckthorn seed oil (SBSO). Methods:The content of fatty acids (FAs) in the SBSO for injection was determined using high-performance liquid chromatography (HPLC) methods.

purpose: The aim of the present study was to find out if nanosuspensions (and microsuspensions) are as good (in terms of exposure and safety) as a solution at different doses. Methods:BX211 used as a model compound of insoluble drugs, was ground in a planetary ball mill. The particle size was measured by laser diffraction and the stability of the particle sizes was monitored.

Purpose:Felodipine is a calcium channel antagonist, which is water insoluble and only 15% bioavailable when administered orally. In this study softgels, with a solubilized-drug core, were used to improve the solubility and consequently the bioavailability of felodipine. Drug solutions were prepared using both cosolvency and micellar solubilization.

Purpose: The effects of infusion speed and dilution on the severity of phlebitis in rabbits were investigated in order to find an effective method for reducing the phlebitis associated with epirubicin injection.

Purpose:To prepare magnetic solid lipid nanoparticles (MSLN) containing Ibuprofen (IB) by an emulsification dispersion-ultrasonic method. Methods: Ibuprofen (IB) was chosen as a model drug loaded on MSLN.

Purpose: The present investigation was carried out to optimize the drug release pattern of a sustained release dosage form of metoprolol succinate. Method: The preparation of MS (metoprolol succinate) microspheres was carried out using poly (ε-caprolactone) at different polymer: drug ratios from 1:1 to 7:1 and 10:1 (F1 to F7 and F8) by the emulsion-solvent evaporation method.

Purpose: To develop and validate a simple and reliable reversed–phase high-performance liquid chromatographic method for the simultaneous determination of notoginsenoside R1, ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1 and icariin in “Qihuotongqiao” tablets composed of Panax notoginseng and Herba epimedii extracts.