Formulation and Process Development Articles

Determination of Letrozole in Tablet Formulations by Reversed Phase High Performance Liquid Chromatography

Purpose: To develop a simple, rapid, accurate and cost-effective reversed phase high performance liquid chromatography (RP-HPLC) method for letrozole in bulk and in tablets. Methods: Development of a method for the determination of letrozole, an anti-cancer drug, by RP-HPLC was undertaken using a new mobile phase of acetonitrile:water (50:50, v/v). The eluent was monitored at 265 nm.
Journal: 
Trop J Pharm Res, October 2010; 9(5)
Full Article Link: 
Click Here
Articles: 
Formulation and Process Development Articles

In Vitro Anticholinesterase and Inhibitory Effects of the Aqueous Extract of Combretum molle (Combre-taceae) Leaf on Rabbit Breathing

Purpose: In previous studies, the aqueous extract of Combretum molle was shown to inhibit disturbances of breathing induced by acetylcholine. The aim of this study was to elucidate the mechanism of this inhibition.
Journal: 
Trop J Pharm Res, October 2010; 9(5)
Full Article Link: 
Click Here
Articles: 
Formulation and Process Development Articles

Acute and Sub-chronic (28-day) Oral Toxicity Studies of Hydroalcohol Leaf Extract of Ageratum conyzoides L (Asteraceae)

Purpose: Ageratum conyzoides is an annual herbaceous plant commonly used in African traditional medicine as a purgative, antipyretic, anti-ulcer and wound dressing agent. The objective of this study was to investigate the acute and sub-chronic toxicity of A. conyzoides leaves in Wistar rats.
Journal: 
Trop J Pharm Res, October 2010; 9(5)
Full Article Link: 
Click Here
Articles: 
Formulation and Process Development Articles

Immunomodulatory Activity of the Methanol Extract of Amorphophallus campanulatus (Araceae) Tuber

Purpose: Traditionally, Amorphophallus campanulatus tuber is used for the treatment of enlarged spleen, rheumatism and tumour. Therefore, this study was designed to evaluate the immunomodulatory activity of the plant material.
Journal: 
Trop J Pharm Res, October 2010; 9(5)
Full Article Link: 
Click Here
Articles: 
Formulation and Process Development Articles

Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphism: An Observational Study among Diabetic Hypertensive Subjects in Malaysia

Purpose: This study investigated the influence of angiotensin-1 converting enzyme (ACE) insertion-deletion (ID) gene polymorphism on the treatment responses of type 2 diabetic subjects at varying stages of nephropathy to ACE inhibitors (ACEI) with regard to blood pressure (MAP) and renal response (GFR).
Journal: 
Trop J Pharm Res, October 2010; 9(5)
Full Article Link: 
Click Here
Articles: 
Formulation and Process Development Articles

Attitudes and Perceptions of Healthcare Providers and Medical Students Towards Clinical Pharmacy Services in United Arab Emirates

Purpose: To explore healthcare providers' (HCPs) and medical students' attitudes to, and perceptions of the pharmaceutical services that clinical pharmacists can provide in United Arab Emirates. Methods: A total of 535 participants (265 HCPs and 270 medical students) were asked to complete a questionnaire over a period of three months (January through March 2009).
Journal: 
Trop J Pharm Res, October 2010; 9(5)
Full Article Link: 
Click Here
Articles: 
Formulation and Process Development Articles

Knowledge, Perception and Attitude of Community Pharmacists towards Generic Medicines in Karachi, Pakistan: A Qualitative Insight

Purpose: In an era of escalating healthcare costs and ageing population, there is a need for cost-effective measures. This study was aimed to investigate the knowledge, perception and attitude of community pharmacists towards generic medicines.
Journal: 
Trop J Pharm Res, August 2010; 9(4)
Full Article Link: 
Click Here
Articles: 
Formulation and Process Development Articles

Medication Administration Errors Involving Paediatric In-Patients in a Hospital in Ethiopia

Purpose: To assess the type and frequency of medication administration errors (MAEs) in the paediatric ward of Jimma University Specialized Hospital (JUSH), Jimma, Oromia Region, southwestern Ethiopia.
Journal: 
rop J Pharm Res, August 2010; 9(4)
Full Article Link: 
Click Here
Articles: 
Formulation and Process Development Articles

A Comparative Study of the Pharmacokinetics of Conventional and Sustained-release Tablet Formulations of Aceclofenac in Healthy Male Subjects

Purpose: To examine the pharmacokinetics of a formulated aceclofenac sustained release tablet formulation and determine if it is bioequivalent to a commercial brand of aceclofenac immediate release tablet (Zerodol(r) 100 mg).
Journal: 
Trop J Pharm Res, August 2010; 9(4)
Full Article Link: 
Click Here
Articles: 
Formulation and Process Development Articles

Quality Control Tests on Andrographis paniculata Nees (Family: Acanthaceae) – an Indian ‘Wonder’ Plant Grown in Nigeria

Purpose: To characterize the aerial parts of Andrographis paniculata, a bitter Indian herb grown in Nigeria, for the purpose of quality control. Methods: The determination of bitterness value and of various physicochemical characteristics; tests for key phytochemicals; and thin layer chromatography (TLC) of the air-dried herb, were carried out as prescribed in standard texts.
Journal: 
Trop J Pharm Res, August 2010; 9(4)
Full Article Link: 
Click Here
Articles: 
Formulation and Process Development Articles

Antitubercular and Phytochemical Investigation of Methanol Extracts of Medicinal Plants Used by the Samburu Community in Kenya

Purpose: To determine the potential benefits of nine medicinal plants used by the Samburu community for the treatment of tuberculosis.
Journal: 
Trop J Pharm Res, August 2010; 9(4)
Full Article Link: 
Click Here
Articles: 
Formulation and Process Development Articles

Improved Production of Pharmacologically-active Sclerotiorin by Penicillium sclerotiorum

Purpose: The aim of this work was to study the optimum conditions for the production of sclerotiorin, a highly active secondary metabolite of Penicillium sclerotiorum under different cultural media.
Journal: 
Trop J Pharm Res, August 2010; 9(4)
Full Article Link: 
Click Here
Articles: 
Formulation and Process Development Articles

Development and Evaluation of Controlled-Release Bilayer Tablets Containing Microencapsulated Tramadol and Acetaminophen

Purpose: To develop and characterize bilayer tablet formulations of tramadol HCl (TmH) and acetaminophen (AAP) microparticles.
Journal: 
Trop J Pharm Res, August 2010; 9(4)
Full Article Link: 
Click Here
Articles: 
Formulation and Process Development Articles

Effect of Cream Formulation of Fenugreek Seed Extract on Some Mechanical Parameters of Human Skin

Purpose: To determine the effect of an emulsion formulation of fenugreek (Trigonella Foneum-Graecum L) seed extract on some mechanical parameters of the skin of healthy human volunteers
Journal: 
Trop J Pharm Res, August 2010; 9(4)
Full Article Link: 
Click Here
Articles: 
Formulation and Process Development Articles

Formulation of Nimesulide Floating Microparticles Using Low-viscosity Hydroxypropyl Methylcellulose

Purpose: To formulate prolonged-release floating microparticles that would minimise the irritant effect of weakly acidic drugs, such as nimesulide, on the stomach by avoiding direct contact with gastric mucosa.
Journal: 
Trop J Pharm Res, June 2010; 9(3)
Full Article Link: 
Click Here
Articles: 
Formulation and Process Development Articles

Formulation of Sustained-Release Diltiazem Matrix Tablets Using Hydrophilic Gum Blends

Purpose: To develop sustained release matrix tablets of diltiazem hydrochloride (DTZ) using karaya gum (K) alone or in combination with locust bean gum (LB) and hydroxypropyl methylcellulose (H).
Journal: 
Trop J Pharm Res, June 2010; 9(3)
Full Article Link: 
Click Here
Articles: 
Formulation and Process Development Articles