Formulation and Process Development Articles

The 36th FACSS conference, sponsored by the Federation of Analytical Chemistry and Spectroscopy Societies, will be held October 18–22, 2009, at the Marriott Hotel in Louisville, Kentucky.

Plenary Sessions

As described in the previous column (1), often there is confusion in multidisciplinary uses of statistical methods for analytical methods due to the variation in terminology, assumptions, and specific uses within different technical disciplines.

Vibrational spectra are of interest to analytical and materials scientists because of their potential to yield nondestructively detailed information on materials. This is because the vibrations quite sensitively reflect interatomic bonding. There are several spectroscopies in which vibrational transitions can be detected. The simplest is infrared (IR) absorption.

Efficient creation, transport, containment, and detection of ions are issues at the core of mass spectrometry. Improvement in any of these areas leads to improved overall performance of the mass spectrometer. As in most sequences of operations, maximum performance benefits usually are obtained with improvements at the beginning of the sequence.

My first (and so far, only) wife recently gave me a gift: a black scarf that she had crocheted. The scarf wasn't all black — positioned at appropriate positions were colored yarn so that the scarf mimicked the visible emission spectrum of hydrogen! (OK, so both my wife and I are geeks . . .

The application of laser-induced breakdown spectroscopy (LIBS) for the analysis of aerosol systems is a challenging problem that entails a wide range of physical phenomena that are coupled to the ultimate analyte response.

In the third installment of this tutorial, the authors explain the determination of the isotopic composition of a sample from a mass spectrometric measurement, and the methods of calculation as well as the units used. This tutorial outlines the practices in common usage so that researchers new to this field can obtain a good understanding of the fundamentals involved.

In the recent years, particularly in the last two decades, a great deal of technological and scientific research has been devoted to the development of rate-controlled oral drug delivery systems to overcome physiological problems, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET), in order to be able to formulate gastro-retentive dosage forms, which will al

Purpose: Astragaloside IV (AGS-IV), the main active constituent of the Chinese medical herb, Astragalus membranaceus, is reported to exhibit a variety of cardiovascular pharmacological actions. However its poor aqueous solubility affects its oral absorption which limits its development as a treatment and its preclinical investigation.

Purpose: The nutritional products for patients with liver failure available on the Japanese market contain many branched-chain amino acids (BCAAs), such as L-leucine, L-isoleucine, and L-valine, which not only have a bitter taste but also strong, unpleasant odours, leading to low palatability.