Formulation and Process Development Articles

purpose: To mask the bitter taste of the widely used antiprotozoal drug, tinidazole, and to formulate it into patient-compliant and convenient fast disintegrating tablets. Methods: Taste masking of tinidazole was achieved by microencapsulation using amino alkyl methacrylate copolymers (Eudragit E100) employing the solvent evaporation technique.

Purpose: To evaluate the antibiotic activity and possible loss of antibiotic activity due to the complexation process and to confirm the synergistic effect of the tetracycline-sucralfate acidic complex. Method: Tetracycline-sucralfate complexes were prepared and their antibiotic activity against two bacteria was investigated.

Purpose: Different marketed samples of cefuroxime sodium for injection, reconstituted under similar conditions, exhibited differences in reconstitution time. The contribution of variables like the solid form, particle size distribution, hygroscopicity, moisture content and wettability towards variations in the reconstitution time of cefuroxime sodium for injection was assessed.

Purpose: Meloxicam is a non-steroidal anti-inflammatory drug with highly variable bioavailability due to its poor aqueous solubility and dissolution. This work aimed to improve meloxicam bioavailability by formulating it in orodispersible capsules containing a soluble complex of the drug with beta-cyclodextrin.

Purpose: The purpose of this study was to evaluate the ability of a quantitative prediction method using a taste sensor to determine the bitterness of orally disintegrating famotidine tablets for use in hospital as a commercial generic medicine from an ethical viewpoint.

Purpose: The aim of this research was to develop in situ gelling, bioadhesive nasal inserts of tramadol hydrochloride. Methods: Nasal inserts were prepared by lyophilization of polymer gel solutions. A 32 factorial design was used to investigate the combined effect of two independent formulation variables in the preparation of the nasal inserts.

Purpose: A simple reversed-phase HPLC method has been developed for determination of indomethacin in rat plasma, excised skin and muscle samples. Methods: The mobile phase consisted of methanol and 0.5% glacial acetic acid in distilled water (75:25 v/v) at a flow rate of 1.0 ml/min. Propylparaben was used as the internal standard (IS) and the detector wavelength was set at 266nm.

Purpose: To characterize the drug release behavior of three-layered tablets consisting of chitosan and xanthan gum. Methods: Three-layered tablets containing 1:1 chitosan and xanthan gum and 75% lactose were prepared by a direct compression technique to control the release of propranolol HCl.

Ordered mixing is an alternative to perfect mixing to achieve a more homogeneous mixture than that obtained by random mixing. An ordered mix can be achieved by dry mixing, triboelectrification, milling, adhesion, coating, and fluidization processes. Ordered mixing regulates the particle size of the drug and alters the particle shape to minimize segregation and agglomeration.

Purpose: To develop new solid dispersions of benzoic acid (BA) and salicylic acid (SA) using Beta zeolite and to investigate the molecular states of the drugs in the pores. Methods: Zeolites, BEA12.5, BEA150 and Fe-BEA, were used. Solid dispersions of 30%BA or SA-70%BEA were prepared by solvent evaporation and sealed-heating.