Effects of Sample-Dissolving Solvents and Sample Ionic Strength in Routine CE Operation

What impact can choice of solvent have on the separations obtained in CE?

Sample diluent ionic strength, pH, organic solvent composition, and viscosity can all have a significant impact on the performance of CE separation. It is, therefore, essential that the choice of solvent is optimized during method development. The optimized diluent should be fully specified in the method and used consistently in method validation and all subsequent applications of the method.