Hardware and Software Challenges for the Near Future: Structure Elucidation Concepts via Hyphenated Chromatographic Techniques

Choosing and effectively employing analytical technology is the broader discussion that underlies the diversity of topics that appear in this installment of "MS—The Practical Art." Over the last five years, we have presented the reasoning of the practitioners we consult, to disseminate their wisdom and further our own knowledge in a number of areas such as accurate mass measurement, sample preparation, modern small-particle ultrahigh-pressure liquid chromatography (UHPLC) technology, and evaluating the viability of emerging non-LC ionization prospects.

In almost every instance, I relied on the expertise of well-recognized practitioners, not only for their "nuts-and-bolts" explanations but for the unique insight their experience affords. Insights developed from their well-earned knowledge we cannot glean from reading peer-reviewed work.

This month, Drs. Kind and Fiehn discuss small-molecule structure elucidation (excluding peptides) using hyphenated chromatographic techniques, mass spectrometers, and other spectroscopic detectors. Their opinions help us glimpse the hardware and software challenges that we face in the near future.

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