Nanoparticulate Drug Delivery Systems For Breast Cancer Therapy

Interview With Professor Ambikanandan Misra and Scahin Naik

Sachin Naik has been awarded as a "Scholar-in-Training Award" by American Association of Cancer Research for his work on "Nanoparticulate Drug Delivery Systems For Breast Cancer Therapy" supervised by Professor Ambikanandan .

Pharminfo.net interviewed Prof.Misra & Sachin regarding their achievements and future of the project.

About the research work

The awarded research work is on the development of RGD grafted docetaxel PLGA nanoparticles for breast cancer therapy. Which includes the preparation of the Docetaxel (anticancer drug) encapsulation in Poly lactide-co glycolic acid (PLGA) nanoparticles with the size range of 200-300nm. PLGA being a biodegradable polymer does not produce any side effect and carries the drug to the cancer cell. Arginine-Glycine-Aspartic acid (RGD) attachment to the nanoparticles provides breast cancer cells specific drug delivery. In vitro cytotoxicity study reveals that the RGD grafted nanoparticles systems are 4 fold more effective as compared to free drug solution on breast cancer cells at equivalent drug concentration. The RGD grafted nanoparticles systems also arrest high amount of DNA in the cell cycle phase G2 and produces more apoptotic cell fragment by initiating programmed cell death. The work is in progress to provide meaningful contribution to the knowledge of Breast cancer therapy.

About Prof. (Dr.) Ambikanandan Misra
http://www.msubaroda.ac.in/techo/upload/ANM.pdf

About "Scholar-in-Training Award" News

http://www.pharmainfo.net/campus-news/international-award-scholar-breast...