Targeted drug delivery systems

Abstract:

The review aims majorly on four areas namely: Architecturing, Synthesis, Properties & Applications of the dendrimer. The unique architectural design of dendrimers, high degree of branching, multivalency, globular architecture and well-defined molecular weight, clearly distinguishes these structures as unique and optimum nanocarriers in medical applications such as drug delivery, gene transfection, tumor therapy, diagnostics, etc. Synthetic approaches lead to a dendritic architecture with properties amenable to modifications of shape, size, polarity, surface properties and internal structure.

Abstract:-

Target delivery of drug molecules to brain is one of the most challenging research areas in pharmaceutical sciences. The blood-brain barrier (BBB) represents an insurmountable obstacle for a large number of drugs, including antibiotics,antineoplastic agents, and a variety of central nervous system (CNS)-active drugs, especiallyneuropeptides.

Swarnlata Saraf

There has been keen interest in the development of a novel drug delivery system. Novel drug delivery system aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and target the active entity to the site of action.

A number of novel drug delivery systems have emerged encompassing various routes of administration, to achieve controlled and targeted drug delivery, magnetic microcarriers being one of them. These microcarriers include magnetic microspheres, magnetic liposomes, magnetic nanoparticles, magnetic resealed erythrocytes, magnetic emulsion etc. Magnetic micro/nanoparticles & molecular magnetic labels have been used for great number of application in various areas of biosciences, targeted drug delivery, imaging & in bioseparation technology. This review paper will discuss about mechanism of magnetic targeted drug delivery, benefits and drawbacks of magnetic targeting, magnetic carriers, and application of magnetism in targeted drug delivery and some other field.