Latest Reviews

Shailesh Sharma

During the past three decades significant advances have been made in the area of novel drug delivery. This was in part due to the evolving discipline of biopharmaceutics, pharmacokinetics and pharmacodynamics.

Rashmi

Topical drug administration is a localized drug delivery system anywhere in the body through ophthalmic, rectal, vaginal and skin as topical routes. Skin is one of the most readily accessible organs on human body for topical administration and is main route of topical drug delivery system.

The skin of an average adult body covers a surface area approximately 2m² and receives about one third of the blood circulating through the body. An average human skin surface is known to contain, on the average 40-70 hair follicles and 200-300 sweat ducts on every square centimeter of the skin. Although skin has been divided histologically into the stratum corneum, the living epidermis and the dermis, collectively it can be considered a laminate of barrier, permeation of this laminate can occur by diffusion via:

Yogesh Murti

A drug that is structurally very similar to already known drugs, with only minor differences. The term "me-too" carries a negative connotation. However, me-too products may create competition and drive prices down¹.

The majority of the new products the industry puts out, are “me-too” drugs, which are almost identical to current treatments but “no better than drugs already on the market to treat the same condition.” Around 75 percent of new drugs approved by the FDA are me-too drugs. They can be less effective than current drugs, but as long as they’re more effective than a placebo, they can get the regulatory green light².

Parag A. Kulkarni

Edible vaccines play a vital role in immunization. Antigens or antibodies expressed in plants (transgenic plant) can be administered orally through edible parts of the plant.

Mr. D.A. Dube

The term sports injury, in the broadest sense, refers to the kinds of injuries that most commonly occur during sports or exercise.

Some sports injuries result from accidents; others are due to poor training practices, improper equipment, and lack of conditioning, or insufficient warm up and stretching.

Ashish Jain

Optimization of drug delivery through human skin is important in modern therapy. With the limitations of oral drug delivery and the pain and needle phobias associated with traditional injections, drug delivery research has focused on the transdermal delivery route.

Sachin Patil

Polysaccharides are polymers of simple sugar building blocks. Crosslinked polysaccharides are having many applications in pharmaceuticals.

Different methods are available for crosslinking of polysaccharides. Different chemical and physical methods are summarized and discussed. Chemical crosslinking of polysaccharide is highly versatile method with good mechanical stability. However, the crosslinking agents used are not only affects the integrity of substances but are often toxic compounds, which have been extracted from gel before they can be applied. Such adverse effects are avoided with the use of physically crosslinked gels.

Dwivedi Sumeet

Indore district sustain a very rich traditional medicinal plant wealth and inherits unique plant and animal communities.

Due to deforestation, loss of biodiversity and indiscriminate exploitation of wild and natural resources many valuable herbs like Abrus precatorious, Bauhinia variegta, Mucuna prurita ets are in the verge of extinction. The present paper enumerates status, conservation strategies and traditional uses of 86 plant species by the ethnic and rural people of Indore district of Madhya Pradesh. The claims were gathered by interviewing traditional healers, especially villagers, of the study area. Attempt was made to verify the efficacy of claims with actual beneficiaries, though it was not possible in all cases due to social customs.

Gharate M.K.

The immune system is the body's defense system. In order for cancer to occur, the immune system must have failed. Dendritic cells are found in all tissues of the body, and many of them began as macrophages.

The first dendritic cell discovered is found throughout the skin and is called a Langerhan's cell. Dendritic cells are a specific type of "antigen-presenting cell." They attach themselves to antigens and alter them in a manner that will allow T-lymphocytes to recognize them. The T-lymphocytes then become sensitized to that specific antigen and attack any cell carrying that exact antigen.

Amol A. Kulkarni

Acquired Immuno Deficiency Syndrome (AIDS) is a systemic and fatal disorder produced by Human Immuno deficiency Virus (HIV), which is retrovirus of the lentivirus family originally reffered to HILV-III or Lav.

By leading to the destuction &/or functional impairement of cells of immune system, notably CD4+ T cells.HIV progressively destroys the body’s ability to fight infection leads to severe depletion of CD4+ T-lymphcytes resulting in opportunistic infection,neurologic and neoplastic disease and ultimately death. Identification of molecular events critical to virus replication has enabled the solution of several strategies for potential chemotherapeutic intervention.