Novel Drug Delivery Approaches to bypass P- Glycoprotein Efflux Pump
Submitted by mukeshgohel on Tue, 05/03/2011 - 01:20Key Words: MDR1, ABCB1, P-gp efflux pump, P-gp substrates, P-gp inhibitors, MRP
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Pharmaceutical Industry In Global Market: Issues To Be Handled For Better Growth
Submitted by ganesh.nirma on Thu, 04/21/2011 - 06:57Abstract:
In the global market, the position of the pharmaceutical industry is not parallel as compared to other information and technology based industries.
Among the Leading industries, the pharmaceutical industry lacks behind in the growth rate as far as innovative research, capital investment and
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Risk Assessment Of Non Steroidal Anti-Inflammatory Drugs
Submitted by pharmacistdixon on Fri, 03/25/2011 - 16:50Abstract
Non steroidal anti-inflammatory drugs (NSAIDs) have a great history of over 100 years as pain killers. Aspirin is one among the pioneer and long used
NSAID. But now a day it is seldom used as NSAID because of the entry of safer, newer NSAID molecules. All new NSAIDs are not safer than the previous
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Amyloids and Amyloidosis: An overview on mis-folded proteins and their diseases
Submitted by Selva krishnamoorthy on Mon, 03/14/2011 - 01:28Abstract
Proteins undergo intra-molecular self-assembly processes to form a stable conformation in order to perform diverse and most essential processes in
living organisms. This regular process can be disturbed with mis-folding phenomenon which leads to the formation of insoluble amyloid fibrils resulting
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Prophylactic Effect Of Caffeine Towards Type 2 Diabetes
Submitted by hemasree on Sat, 02/26/2011 - 15:23Abstract:
Type 2 diabetes accounts for about 95% of total diabetic individuals. Its prevalence is increasing these days. This article revises the effect of
caffeine on type 2 diabetes and its mechanisms. Type 2 diabetes is characterized by two conditions: insulin resistance and β cell dysfunction leading
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Biosimilar Growth Hormone: Need For Caution
Submitted by sandeepkhare on Tue, 01/18/2011 - 23:15Abstract
The use of biosimilar drugs is increasing. This article reviews the differences between generics and biosimilars, points out the shortcomings in the
regulatory process for biosimilars, and draws attention to the limitations and potential problems of prescribing biosimilars, while focusing on human
growth hormone.
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New Drug Approval Process: Regulatory View
Submitted by drharishdureja on Sat, 12/11/2010 - 22:19Abstract
A regulatory process by which a person/organization/sponsor/innovator gets authorization to launch a drug in the market, is known as drug approval process. In general, a drug approval process comprises of various stages: application to conduct clinical trials, conducting clinical trials, application to marketing authorization of drug and post-marketing studies. Every country has its own regulatory authority, which is responsible to enforce the rules and regulations and issue the guidelines to regulate the marketing of the drugs.
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Indian National GLP (Schedule L1) In Comparison To WHO GLP- A Review
Submitted by TANUSHRI MUKHERJEE on Thu, 11/11/2010 - 19:19Abstract
The objective of the review article is to bring out the differences between the Schedule L1 , Drugs and Cosmetics Act, 1940, Government of India and the WHO Good Practices For Pharmaceutical Quality Control Laboratories, World Health Organisation. This will be particularly useful to the laboratories that already comply with the requirements of Schedule L1 and want to move ahead towards WHO compliance.
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Glucagon Like Peptide -1 : A New Era In Treatment Of Type - 2 Diabetes Mellitus
Submitted by manmohansinghal on Sun, 10/31/2010 - 23:39Process Validation : An Essential Process In Pharmaceutical Industry
Submitted by phviral on Fri, 10/01/2010 - 16:21
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POLYOX (Polyethylene Oxide) - Applications in Pharma Industry
Submitted by Saritha R Bhandary on Wed, 09/22/2010 - 22:38Abstract
The purpose of this review article is to describe the properties and applications of polyethylene oxide. Polyethylene oxide is a biocompatible polymer, which is marketed as "POLYOX TM". It is a non-ionic, water soluble resin, with good lubricating, binding and film forming properties. POLYOX TM retards the release rate of drug/s and hence are widely used in pharmaceutical formulations like controlled release dosage forms, hot-melt technology and mucoadhesive dosage forms.
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Global Regulatory Perspective of Bulk Pharmaceutical Excipients
Submitted by lakshmanapramod on Fri, 09/03/2010 - 18:36Abstract:
Regulations for pharmaceutical bulk excipients are stringent as same as pharmaceutical medicines. In case of new excipient, applicant has to submit safety & quality data. In case of approved or existed excipient applicant has to submit literature reference data i. e. FDA inactive ingredients guide, the national formulary, U.K. ABPI data sheets as part of the drug submissions. In U.S, FDA assesses & permits use of excipients as part of a new drug application (NDA). In E.U, it is assumed that novel excipients need to be evaluated as new chemical entities.
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Polycystic Ovary Syndrome : A Major Cause Of Female Infertility
Submitted by vikas.gupta1911 on Wed, 06/30/2010 - 15:41Compression of Coated Multiparticulates
Submitted by sailesh on Mon, 06/14/2010 - 15:14Abstract: -
Multiparticulate drug delivery systems consist of large number of discrete units, each exhibiting desirable characteristics. They are especially suitable for achieving controlled or delayed release of the drug with lower risk of dose dumping. Various techniques like spheroidal oral drug absorption system (SODAS), programmable oral drug absorption system, pelletized delivery system, and pelletized tablet system were developed for oral delivery of multiparticulates. Pelletized tablet consists of polymer coated drug pellet compressed into a tablet.
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Fast Dissolving Tablets: An Overview
Submitted by rahulghaste on Wed, 06/09/2010 - 21:58Abstract:
The need for delivering drugs to patients efficiently with minimum side effects has prompted pharmaceutical industries to be engaged in development of new drug delivery systems. Pediatric and geriatric patients find it difficult to swallow solid dosage forms like tablets. Mouth dissolving tablet that dissolve or disintegrate rapidly in oral cavity result in solution, is an ultimate remedy for this problem. In addition they give pleasing mouth feeling. MDT has advantages such as patient compliance, quick onset of action, improved bioavailability, etc.
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Proniosome Gel : Potential Carrier System in Topical/Transdermal Delivery for Drugs and Cosmetics/Cosmeceuticals
Submitted by nand_kishore on Mon, 05/31/2010 - 16:35Abstract
Proniosomal gel is nonionic surfactant based vesicle system which exists in different liquid crystalline phases. Mixing of the surfactant in an alcohol and limited hydration with aqueous phase leads to the formation of proniosomal gel. Due to the limited amount of water present, these systems behave as viscous phases. The various phases of liquid crystalline structures can be utilized as such for topical/transdermal applications or can be used after further hydration to form niosomes.
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Genotoxic Impurities In Pharmaceuticals
Submitted by poonmphar on Mon, 05/24/2010 - 11:23Decisions to approve, prescribe and consume medicines involve risk/benefit assessments by regulatory agencies, health care professionals and consumers. For serious or life threatening conditions, drugs with higher risks for adverse effects or for serious adverse effects are sometimes acceptable. For example, some life-saving cancer chemotherapies are known human carcinogens. However, if one is suffering from a life threatening tumor, a 5% risk of a secondary, treatment-related tumor is generally considered acceptable.
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Colon targeted drug delivery system - an overview
Submitted by purushothaman on Sat, 05/15/2010 - 20:49Abstract
By definition, colonic delivery refers to targeted delivery of drugs into the lower GI tract, which occurs primarily in the large intestine (i.e. colon). Targeted drug delivery to the colon would therefore ensure direct treatment at the disease site, lower dosing and fewer systemic side effects. In addition to local therapy, the colon can also be utilized as a portal for the entry of drugs into the systemic circulation.
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Apoptosis: Concept, Mechanisms and Clinical Implications
Submitted by pushkar kalantri on Mon, 05/03/2010 - 02:20Career opportunities for the pharmaceutical professionals in pharmaceutical industry
Submitted by Arup Manna on Sat, 04/17/2010 - 19:33Abstract
Objective of this article is to highlight the scope of career opportunity for the pharmacy professional in Pharmaceutical Industry. Although job avenues for pharmaceutical professionals are with pharmaceutical industry, government departments, universities, teaching, hospitals, investigation and research institute etc, present discussions is restricted mainly to point out the career opportunity of pharmaceutical professionals in Industry. At the outset the article depicts the portrait of vast and growing industry pharmaceutical industry.
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Carriers/Vesicle based approaches for penetration enhancement in transdermal drug delivery system
Submitted by Geeta Aggarwal on Tue, 03/30/2010 - 18:24Abstract:
Skin is an important site of drug application for both local and systemic effects. For transdermal delivery of drugs, stratum corneum (SC) is the main barrier for permeation of drug. So to circumvent the SC, different approaches of penetration enhancement are used. Carriers/vesicles such as liposomes, niosomes, ethosomes, microemulsions, complexes, prodrugs provide better alternative method to enhance permeation of drugs through skin.
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