Hydrogel Nanoparticles

Submitted by Shiv Majumdar on Sat, 11/07/2009 - 10:06

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ULURU (Manufacturing comapny) are developing a novel biomaterial that utilises hydrogel nanoparticle aggregates to form a material of varying strength and function. The aggregate is then implanted into the body to form a permanent, porous hydrogel implant
The company has stated its intention to pursue the first application of this technology as dermal filler, but a secondary application has been highlighted in drug delivery. This is done by incorporating the drug into the interstitial spaces between the nanoparticles during formation of the aggregate from the aggregate once implanted in the body
Interestingly, the size of these spaces can be tailored to the particular drug of choice and the company has been able to encapsulate proteins within the lattice, which are then slowly released
Moreover, as the drug / nanoparticle aggregation is performed in water solutions, this is an advantage over solvent solutions which are often used in other drug delivery materials

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dear sir, very interesting

Submitted by SUPRIYA VAVILAPALLI on Wed, 11/11/2009 - 15:15.

dear sir,
very interesting topic......sir what about the bioavailability of these type of drugs?

SUPRIYA VAVILAPALLI

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Bioavailability

Submitted by Shiv Majumdar on Thu, 11/12/2009 - 07:45.

Dear supriya,

Thanks for the words.

Bioavialability will be higher due to reduction of particle size to nano-range & miscibility of solvent phase with body fluids.

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Shiv
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Dear sir, even i have same question ....

Submitted by Kranthi Kumar on Mon, 11/09/2009 - 15:40.

Dear sir,
Eve i have same doubt as that of zarrin have. you have mentioned "as the drug / nanoparticle aggregation is performed in water solutions, this is an advantage over solvent solutions which are often used in other drug delivery materials" why is it so ? can you explain about it.

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Water as solvent

Submitted by Shiv Majumdar on Tue, 11/10/2009 - 06:16.

Dear Kranthi,

The answer is very simple that as water is universal solvent & moreover if we consider in-vivo fate of the drug delivery system, the solvent plays an important role, as water is miscible with body fluid hence shows better bioavailability. I gave Farria Zarin few references & their link, so you can check that for further references.

Reagrds
Shiv
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Dear sir, Good information

Submitted by Zarrin Faria on Mon, 11/09/2009 - 04:36.

Dear sir,
Good information about this new technology.....as the technology is becoming more complex so are the side effects...the harmful effects on the body...What can be the side effects of this technology on the body parts?
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Faria Zarrin
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Another reference

Submitted by Shiv Majumdar on Mon, 11/09/2009 - 07:28.

Mehrdad Hamidia,Amir Azadia and Pedram Rafieia, "Hydrogel nanoparticles in drug delivery"Advanced Drug Delivery Reviews,Volume 60, Issue 15, 14 December 2008, Pages 1638-1649 ,

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Dear Farria zarrin, About

Submitted by Shiv Majumdar on Mon, 11/09/2009 - 07:24.

Dear Farria zarrin,

About your query, yes few side effects are associated with this but that are generalised side effects associated with Nanotechnology. i am sending reference & its link, you can check for further details.

REFERENCE: Health Effects of Nanoparticles, http://www.irsst.qc.ca/files/documents/PubIRSST/R-469.pdf

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Shiv
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Sir.. Thats a very

Submitted by Sirisha Pingali on Sun, 11/08/2009 - 15:23.

Sir..
Thats a very interesting blog..I think hydrogel nanoparticles ll be the study of interest in future..Thank you for sharing such a nice information.

Sirisha Pingali
www.pharmainfo.net/sirisha